Cryst APC - crystallization advanced process control

Project applicant

University of Zagreb, Faculty of Chemical Engineering and Technology Laboratory for Automation and Control (LAM),, Savska c. 16/5a-9, HR-10 000 Zagreb

Project partner

MKP Ltd., Erpenjska 5, HR-10 000 Zagreb

Total project value
Co-financed by the EU

Project implementation period

2020/12/15 – 2023/12/15


  • Analysis of the active pharmaceutical ingredient (API) and a suitable solvent for crystallization
  • Determination of solubility curve and metastable zone width for different cooling rates
  • Collection of data from process spectrometers in different concentration and temperature conditions for the development of calibration models
  • Development of a model that continuously estimates the concentration of solute in suspension from spectral data and temperature
  • Collection of data required for the development of a kinetic model of crystallization
  • Determining the method of process control and quality parameters of the final product (crystals)
  • Conducting model validation experiments
  • Determination of the optimal crystallization temperature profile in order to achieve the desired particle size distribution
  • Determining the model of the executive system (thermostat cooling)
  • Optimization of controller parameters for monitoring the set temperature profile in time
  • Development of control programs for spectrometers and thermostats
  • Central server configuration for device access and data acquisition
  • Development of programs for guiding the crystallization process and integration with GMP standards of PAT in industry
  • Selection of variables related to process equipment that significantly affect the quality of collected data
  • Data collection for model development
  • Development of empirical models for predictive diagnostics and alarming in case of irregularities in the operation of instruments and guidance systems