- Analysis of the active pharmaceutical ingredient (API) and a suitable solvent for crystallization
- Determination of solubility curve and metastable zone width for different cooling rates
- Collection of data from process spectrometers in different concentration and temperature conditions for the development of calibration models
- Development of a model that continuously estimates the concentration of solute in suspension from spectral data and temperature
- Collection of data required for the development of a kinetic model of crystallization
- Determining the method of process control and quality parameters of the final product (crystals)
- Conducting model validation experiments
- Determination of the optimal crystallization temperature profile in order to achieve the desired particle size distribution
- Determining the model of the control system (thermostat cooling)
Optimization of controller parameters for monitoring the set temperature profile in time
- Development of control programs for spectrometers and thermostats
- Central server configuration for device access and data acquisition
- Development of programs for guiding the crystallization process and integration with GMP standards of PAT in industry
- Selection of variables related to process equipment that significantly affect the quality of collected data
- Data collection for model development
- Development of empirical models for predictive diagnostics and alarming in case of irregularities in the operation of instruments and guidance systems